Small cell osteosarcoma

Summary
Description

This rare subtype of osteosarcoma accounts for less than 1% of all osteosarcoma tumors. This tumor occurs in the metaphysis of the long bones.

Symptoms and Presentation
Patients present with local pain and swelling.
Brief description of the xray
On x-rays, a blastic lesion it extends into the shaft of the bone with a permeative destructive pattern is seen.
Brief desc of tx
These tumors have a poor prognosis. Chemotherapy and surgery are used.
Tumor Type
Benign or Malignant
Most Common Bones
Location in bone
Periosteal reaction
Position within the bone
Tumor behavior
Tumor density
Complete Information on this Tumor
Introduction and Definition

This rare subtype of osteosarcoma accounts for approximately 1% of all osteosarcomas.

Incidence and Demographics
The most frequent site is the long bones, but there are reports of this lesion occurring in numerous locations, including the calcaneus and in the ulna.
Symptoms and Presentation

Similar to those of conventional osteosarcoma.

X-Ray Appearance and Advanced Imaging Findings
And aggressive, permeative, destructive blastic lesion is seen in the metaphysis of the bone which extends into the shaft.
Differential Diagnosis
Ewing sarcoma, mesenchymal chondrosarcoma, other small cell lesions including lymphoma, Askin tumor, PNET.
Histopathology findings
On microscopic analysis, small cell osteosarcoma shows scanty osteoid formation. There are mostly solid areas of small round or spindle cells that may resemble other small cell sarcomas, such as Ewing sarcoma. The small amount of osteoid formation makes these tumors a challenge for the pathologist. On electromyograph microscopy, no single pathognomonic ultrastructural features have identified.