This disease is rare, and often affects children, more commonly girls than boys. The peak age of incidence is around 10 years, with the range being four to 55 years. Adults can be affected. The number of affected areas varies from 2 to 18.
Children present with pain, deep aching pain, limping, and may also present with fever. The metaphyseal area of long bones, the clavicle, and the shoulder girdle are common locations. Other sites such as the spine, ankle, and foot have been reported.
Dermatological manifestations may occur and include psoriasis, acne, and pustules on the palms of the hands and soles of the feet. Uveitis, and inflammatory bowel disease have also been described.
Majeed syndrome consists of CRMO and congenital dyserythropoietic aneama, has been reported in families. Te LPIN2 gene appears to play a role in these cases.
Skeletal manifestations include multiple synchronous or metachronous lesions appearent on plain radiographs. The lesions are lytic and destructive in the early phase, and sclerotic and reactive in the late phase, occurring in any bone.
A large number of drugs and treatments have been tried with variable success in recurrent or unresponsive cases. Medical management options include nonsteroidal anti-inflammatory drugs, bisphosphates, and oral steroids. Antibiotics do not seem to be helpful. Surgical treatment has been used, but its role is not yet clearly defined.