The peak age of incidence is around 18 or 20. Males are more commonly affected than females. About 600 children are affected each year in the United States. Individuals of all ages can be affected. Older persons are at increased risk for certain types of secondary oseosarcoma tumors, such as post radiation osteosarcoma and post-Paget's osteosarcoma.
The most common presentation is pain and a mass, which occurs near a joint.
On radiographs, conventional osteosarcoma occurs predominately in the metaphysis, and appears as a mixed sclerotic and lytic lesion, that may permeate the bone and the nearby cortex, causing a soft tissue mass and a periosteal reaction.
Before treatment can be planned, a complete oncological staging workup must be completed. For most types of osteosarcoma, treatment is multi-modal, including chemotherapy and surgery.