The incidence of secondary post-radiation sarcoma is related to the incidence of the primary cancers and diseases that are treated with high dose radiation. Published data suggest that males and females were equally affected, with age range 10 to 84 years old years old, and an average age 45.6 years.
Symptoms can go unnoticed for a fairly long time, or be misinterpreted by the patient and the doctor, and then an acute onset of constant and progressive pain and/or swelling occurs.
Radiographs most often shown aggressive pattern, with a mineralized soft-tissue mass and cortical bone destruction within the radiation field, and/or changes such as sclerosis and osteopenia.
A radiation oncologist, medical oncologist, and an orthopedic tumor specialist should be consulted to plan treatment. Surgical options include wide resection with limb salvage, or wide resection with amputation.