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Tumors of Cartilage

Mesenquimales Condrosarcoma

Esta rara forma de condrosarcoma es mortal sarcoma de alto grado de células primitivas mesenquimales y las islas de cartílago que se produce con mayor frecuencia en el fémur, costillas, la mandíbula, el cráneo y la columna vertebral, y puede ocurrir en cualquier hueso.
La mayoría de los pacientes son menores de 40 años, y puede ser 10 a 70. Los hombres y las mujeres son igualmente afectados.
Los pacientes se presentan con dolor y una misa. Las lesiones suelen tener características de densidad punteado de los tumores del cartílago. Pueden ser expansiva y localmente destruyen el hueso.
La resección completa de ancho, con márgenes agresiva de ancho. A largo plazo de seguimiento es necesario. La quimioterapia y la radiación se utilizan cuando la resección completa no es posible, pero el papel de la quimioterapia no está bien definida. el tratamiento multimodal puede ser considerado en algunos centros. La quimioterapia parece estar vinculado a una mejor supervivencia.

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Ollier's syndrome

Ollier disease (enchondromatosis) is a rare, non-inherited disease where multiple enchondromas occur. Some of the enchondromas may become chondrosarcomas.
The lesions appear in childhood and worsen as the child grows. The tumors rarely progress after skeletal maturity.
Patients have shortening, deformity, and pain in multiple bones. All or part of a limb may be involved. The extent of the lesions is variable. Multiple lesions in the metaphysis, epiphysis, and diaphysis grow and expand. The lesions are lytic, expansile, and may cause pathological fracture.
Treatment is needed to repair fractures, support fragile bones, and treat enchondromas that may have become sarcomatous.

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Osteochondroma

Osteochondroma is a benign tumor that occurs in areas of bone and cartilage. Tumors are most often found in the long bones, especially near the knee or shoulder. Lesion can either be sessile or pedunculated.
Occurs in people aged under 20, with a male to female ratio of 1.5: 1
Clinically presents with pain due to mechanical irritation or as a painless mass. Sessile tumors appears as wide ranging with trumpet-shaped deformity. Pedunculated lesions appear distally.


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Osteochondromatosis

HMOCE (hereditary multiple osteochondral exostosis) is a rare, autosomal dominant inherited disease where multiple osteochondral bone tumors occur on the surfaces of the bones. The severity of the disease can vary from mild to very disabling. A small number of the tumors may develop into low grade chondrosarcomas.
The disease is apparent within the first 10 years of life, about 1 in 50,000 are affected.
Patients have noticeable bumps near their joints, especially the knees, hips and shoulders. Patients also have short stature and malalignment of joints.Xrays show multiple lesions on the surface of the long bones, pelvis and elsewhere.
Treatment is required for the large, troublesome lesions, but the others may be observed. The risk of development of sarcoma requires that all patients with this disease ensure regular self-monitoring and follow-up.

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