Further Work Up Needed::
The further workup that is required is transillumination and aspiration. To perform trans illumination, it is generally helpful to work in a low light environment. A small LED penlight or a laser pointer works best, because they create a very focused intense light that can be projected into the mass.
If transillumination is positive, the next up is aspiration. The mass is entered in one single location with a large bore needle. Multiple punctures and multiple pass of the needle are not recommended. Ganglion cyst material can be very thick and resistant to aspiration. Using a large bore needle on a small volume syringe is helpful. The presence of clear ganglion type fluid absolutely confirms the diagnosis and no further workup is needed. Aspiration of old or new blood is NOT considered a sign of a ganglion and mandates further investigation.