Sclerosing Bone Disorders

Sclerosing bone disorders  (Osteopathia striata,  osteopoikilosis, and meloreostosis, Leri's disease, flowing periosteal hyperostosis)

Osteopathia striata (Voorhoeve's disease) is a benign, usually painless disorder characterized by longitudinal dense striations in affected bones.  In meloreostosis, there is thickening of the endosteal and periosteal bone that has been likened to  "candle dripping". Multiple punctate or rounded small bone islands characterize Osteopoikilosis.  Mixed sclerosing bone disorder refers to patients who have manifestations of two or three of these patterns together. 

Meloreostosis, Leri's disease, flowing periosteal hyperostosis

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Osteopoikilosis, spotted bones

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Other rare hereditary and non-hereditary bone disorders marked by sclerosis or longitudinal dense striations in affected bones have been described that may have radiological similarities to the disorders described above.


Bullough and Invigorita, Atlas of Orthopaedic Pathology, 1st Ed. University Park Press
Greenfield and Arrington, Imaging of Bone tumors, Lippencott, 1995


May 7, 2001 HD






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